성견의 발치와 협측골 외측에 적용한 교원질 차단막과 재조합 골형성단백질의 치조제 보존 효과
Application of rhBMP-2 loaded collagen membrane on the buccal plate for ridge preservation: a pilot study in dogs
임현창, 김민수, 양혜주, 이중석, 최성호, 정의원,
소속 상세정보
임현창 ( Lim Hyun-Chang ) - 경희대학교 치과대학 치주과학교실
김민수 ( Kim Min-Soo ) - 연세대학교 치과대학 치주과학교실
양혜주 ( Yang Cheryl ) - 연세대학교 치과대학 치주과학교실
이중석 ( Lee Jung-Seok ) - 연세대학교 치과대학 치주과학교실
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
정의원 ( Jung Ui-Won ) - 연세대학교 치과대학 치주과학교실
KMID : 0362720150530050348
Abstract
Objective: The aim of this study was to determine the effect of multi-layer of a collagen membrane alone or loaded rhBMP-2 on the buccal plate for ridge preservation after tooth extraction.
Material and methods: Following bilateral extraction of the maxillary 1st and 3rd premolars in five dogs, rhBMP-2 loaded
collagen membrane was applied to the buccal plates at the 1st premolar and collagen membrane only was applied to the buccal plates at the 3rd premolar unilaterally. The collagen membranes applied in the experimental groups were piled into four layers. The corresponding sites of the contralateral side healed naturally. After 3months of healing, the animals were sacrificed. Radiographic and histologic analyses were performed.
Results: There was no significant difference in the healing of extraction socket at both 1st and 3rd premolars. In microcomputed tomography, the widths of the residual ridge of the experimental groups were similar with the controls. Histologically, the experimental groups did not exhibit different pattern compared to the controls regardless of the addition of rhBMP-2.
Conclusion: Layering of the collagen membrane with or without rhBMP-2 on the buccal plate failed to show the effectiveness in dimensional preservation of the extraction socket.
키워드
collagen membrane; rhBMP-2; ridge preservation; ridge resorption
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